The Rosalind Franklin Institute (the Franklin) is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.
Within the Next Generation Chemistry theme, one of the aims is to realise the full potential of synthetic methods applied in biological systems as possible new modes of biotechnology. Based on this approach we have developed methods that allow light-mediated control of sugar and proteins, including signalling molecules [see Nature 2016, 540, 574-578, Nature 2020, 585, 530-537]. This has led to the development of a technology in collaboration with Rothamsted Research where ‘light-controlled’ sugar signalling can be activated in plants under the control of simple sunlight to potentiate function (including enhanced yields in crops >10% such as wheat).
You will expand on these discoveries to interrogate the mechanisms that underlie this striking enhancement of plant function. In particular, the project will explore novel methods for tracking the metabolic consequences of this chemical control of plant at the protein, sugar and metabolic level. These will focus on ‘omics’ approaches including proteomics, glycomics, metabolomics and isotope tracer experiments.
The project is funded by UKRI-BBRSC and is a collaboration with Rothamsted Research, University of Oxford and other themes at the Franklin as well as other potential industrial and academic collaborators and experts in the UK and beyond. The post, which is for 2 years in the first instance, reports to the Franklin’s Theme Lead for Chemistry, the Franklin’s Head of Mechanistic Proteomics, the Director of Oxford Chemistry Mass Spectrometry and will work alongside other researchers in the Franklin and at partner university institutes including at the University of Oxford (where the group is jointly based).
• Develop various omics experiments for exploring the consequences synthetic sugar systems in planta.
• Collaborate with industrial and academic partners (especially on planta applications and analytical methods and their implementation).
• Engage collaboratively with other researchers to design hypotheses
• Work with other themes and researchers to develop the burgeoning Franklin environment to be as suitable as possible for such work.
• Develop the scientific scope of the project, formulate relevant research questions, conduct individual research, analysing detailed and complex qualitative and/or quantitative data from a variety of sources, and generate original ideas by building on existing concepts
• Work together with the surrounding facilities to ensure efficient protein production and chemistry at the Franklin and Harwell environment
• Publish research articles in leading academic journals.
• Present findings at national and international meetings/conferences.
• Take a formal or informal role (as required) in the supervision of research students, including recruitment, mentorship and career development.
• Raise research funds through grant applications, and manage own area of a larger research budget.
• Participate in and support the public engagement and widening access activities of the Franklin
• Any other duties that come up in the normal running of the facility and that can be reasonably requested of the post-holder.
• A post-graduate qualification, or equivalent experience, in Chemistry, Biochemistry or Chemical Biology, Biomolecular Science, or related subjects.
• Experience in omics analyses especially proteomics and metabolomics.
• Experience with saccharides, including synthesis, extraction, modification and characterization.
• Experience with developing routinely usable methods.
• Experience with devising research questions and to develop strategies to address them
• Ability to work both independently and as part of a team
• Ability to travel occasionally for training or dissemination of your work.
• Experience with project management and demonstrated ability to deliver agreed milestones in a timely manner, adapt to changing priorities
• Ability to discuss and coordinate experiments with a variety of colleagues from different disciplines
• A demonstrated aptitude for omics system design and analysis.
• Expert knowledge of structural methods.
• Expert knowledge of plant sugars and associated pathways.
• Expert knowledge of carbohydrate-processing enzymes.
• Expert knowledge of plant culture, analysis and phenotypic characterization.
• Knowledge of biological chemistry and bioinformatics.
• Experience with general biophysical techniques such as SPR, ITC, fluorescence, etc.
In return we offer:
• 25 days holidays
• Generous pension scheme (employer’s contribution currently up to 18%)
• Training and development opportunities for staff at all levels
• Bus pass discount scheme
• Access to employee discount platform
• Subsidised canteen
• Free on-site parking
• Campus location in beautiful countryside with social and sports clubs open to staff
Closing date: 22nd March 2021 at 9:00am
Location Harwell and Oxford
Type of Post Full Time
Period of appointment 2 years' fixed term contract
Salary £33,000 - £39,000 per annum
Closing Date 22/03/2021
Ref No 10119