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Senior (Professorial) Research Group Leader

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The Rosalind Franklin Institute is an independent charitable research institute. It represents a partnership of ten leading UK Universities, Diamond Light Source and UK Research and Innovation (UKRI). The Rosalind Franklin Institute will develop new technologies from the physical sciences to provide a transformation in the life sciences.

We are now looking to appoint a world-leading cryo-electron tomographer. The person will be based in the newly completed Hub building at Harwell which has been designed from the outset for development of electron microscopy. The person will benefit from the very close partnership on campus with eBIC (part of Diamond Light Source).

The Franklin has identified electron tomography at cryo temperatures of biological material (cells and tissues) as one of the most promising areas for future developments in imaging in the biological sciences. We are inspired by the pioneering work of Wolfgang Baumeister, whose lab has shown the power of this approach. Our aim is to demonstrate the approach by delivering transformative insights to biomedical problems, for example viral infection, multiprotein complex assembly and regulation in disease, the effects of medicines in the cell and the interface between cells.

We are developing a new generation of plasma FIBs in partnership with Thermo Fisher Scientific (TFS). Building on this partnership we are now developing the next generation of electron microscopes targeted to deliver both ‘tomography in a box’ (a factor of ten improvement in accessibility of tomography) and ‘protein structure in the cell’ (a factor of 10 improvement in information from tomographic experiments). These developments are supported by UKRI, Wellcome Trust and TFS. The project is a flagship for the UK and will involve working closely with researchers in the UK and beyond.

Tomography is an integral part of structural biology theme which includes Protein Purification UK (PPUK) which focuses on novel approaches to specimen production. Activities in correlative imaging, mass spectrometry and in cell chemistry, directly interface with the activity. We expect the applicant to realise these synergies.

Responsibilities

The person will be responsible for driving a world leading scientific research programme in cryo electron tomography. The individual will publish research articles in leading academic journals, train the next generation of scientists and present findings at national and international meetings/conferences. Alongside their own biological research programme, the candidate will play a major role in the development of the Institute. This is a research focused position and there is essentially no University teaching or University service requirement.

The position is a partnership with Universities of Imperial1 and Oxford2.

In return we offer:

• 25 days holidays

• Generous pension scheme (employer’s contribution currently up to 18%)

• Training and development opportunities for staff at all levels

• Bus pass discount scheme

• Access to employee discount platform

• Subsidised canteen

• Free on-site parking

• Campus location in beautiful countryside with social and sports clubs open to staff

Closing date: 15th July 2021, at 09:00am

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