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Tomography Hardware Manager

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The Rosalind Franklin Institute is a new national institute, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology development.

Electrifying Life Science is a major UK wide initiative with the goal of shifting structural biology into a new era of discovery. Spearheaded by the Rosalind Franklin Institute, Diamond Light Source and the MRC-LMB, the initiative has recently been awarded a major grant from the Wellcome Trust.

The Franklin component of Electrifying Life Science has at its core, the AMPLUS project, an ambitious plan to revolutionise electron cryo tomography and enable high-resolution, large-volume visualisation of biological specimens (cryoET). A partnership with ThermoFisher will see the delivery of two cutting edge electron microscopes (Dorothy and Hodgkin) that will sit alongside two state of the art plasma cryo FIBs (Rosalind and Franklin).

The LMB-MRC team lead by Richard Henderson and Chris Russo, are working to deliver a low cost high performance electron microscope, cryoEM100.

Diamond, led by David Stuart and Gwyndaf Evans will deliver an entirely new high energy electron diffraction instrument to revolutionise crystallography (HEXI).

The Wellcome funding allows the Franklin, led by Jim Naismith and Mark Basham, to expand the AMPLUS team and recruit scientists at different levels of experience to work alongside our existing team. We are looking for scientists with expertise in biology, cell culture, instrumentation and hardware development, cryo electron microscopy, and software development. The Franklin will host a suite of advanced instrumentation for structural biology. Ability to work effectively as part of an interdisciplinary team will be vital.

The Franklin will host a suite of advanced instrumentation for structural biology. We are looking to appoint a Tomography Hardware Manager at a senior level. Successful candidate will be responsible for the day-to-day operation of the instruments and will support tomographic analysis. This is a research position and you will work closely with senior post holder Gwyndaf Evans and Jim Naismith. You will be expected to exercise independence at a day-to-day level.

Selection criteria


• A PhD or equivalent advanced laboratory experience.

• Experience with electron microscopy or equivalent advanced hardware.

• Knowledge of technical and scientific challenges of electron microscopy.

• Ability to work as part of a team and independently.

• Excellent written and oral communication skills.

• Awareness of current scientific literature.

• Ability to play an active role in a research program.

• Demonstrated ability to report on scientific progress.


• Experience in operating, repairing or building advanced instrumentation.

• Resource and hardware management.

• Experience of working in partnership with Industry.

• Experience of supervising other members of the team.

In return we offer:

• 25 days holidays

• Generous pension scheme (employer’s contribution currently up to 18%)

• Training and development opportunities for staff at all levels

• Bus pass discount scheme

• Access to employee discount platform

• Subsidised canteen

• Free on-site parking

• Campus location in beautiful countryside with social and sports clubs open to staff

Closing date: 27th November 2020, 9:00am

If you would like to informally discuss this role with Professor James Naismith, please email hr@rfi.ac.uk for this to be arranged.

Applicants should refer to our Candidate Privacy Policy

Area Scientific

Location Harwell

Type of Post Full Time

Period of appointment 5 years’ fixed-term contract

Salary £43,000 - £50,000 per annum

Closing Date 27/11/2020

Ref No 10093


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