We are seeking a talented and highly motivated postdoctoral researcher to work in a team investigating the role of cilia in development and disease.
The lab’s research is concentrated on understanding the relationship between fluid flow, cilia and the polycystin encoding genes Pkd1l1 and Pkd2. We are actively characterising the function of the polycystin protein domains using genetics, cell biology, developmental biology and molecular biology. You will drive research investigating aspects of the lab’s interests. You should be highly motivated, with an understanding of genetics and an interest in using the mouse as a model system (previous experience with mice not essential, as training can be provided).
Our research involves a wide range of techniques, including cell biology, mouse embryology, microscopy/confocal imaging, RNA extraction and qPCR analysis of gene expression, cell and embryo culture and the design of sophisticated mouse genetic experiments, in addition to routine molecular techniques (DNA cloning, sequencing, genotyping etc.). Experience in one or more of these areas would be an advantage.
To join us, you will need a PhD in an appropriate discipline (e.g. Genetics, Cell Biology or Biochemistry). The successful candidate will receive appropriate training during their tenure and be given reasonable support in acquiring/developing essential research skills and transferable/soft skills.
Previous research experience required
- Hands-on experience in genetics research, cell, molecular or developmental biology
- Some experience in more than one area would be an advantage
- The ability to work in a multi-disciplinary team and communicate complex scientific ideas to others
- A proven track-record (e.g. publications/presentations at meetings) in carrying out scientific research to an international standard
The Mammalian Genetics Unit is a UK Medical Research Council unit at the MRC Harwell Institute, an international centre at the forefront of mouse genetics research. Located on the Harwell Campus, just south of Oxford, it is nestled amongst a vibrant community of leading science organisations. We aim to advance medicine through cutting-edge research into the genetic basis of disease. Our research programs span an entire lifetime, from embryonic development to diseases of ageing. They cover many areas, investigating the underlying genetics in disorders of sex development, the relationship between disrupted circadian rhythms and psychiatric disease, the role of cilia in development and disease, age-related deafness and otitis media, neurodegenerative disease and type 2 diabetes.
Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers.